Table 1 shows an overview of some underlying disorders. SFN is associated with a great variety of diseases as underlying mechanisms, but can also present idiopathic. The autono-mic small nerve fibers are responsible for thermoregulatory, sudomotor, cardiovascular, gastrointestinal, urogenital and other autonomic functions. Som-atic small nerve fibers transmit information about temperature, pain and itch. General symptoms are fatigue, cognitive disturbances, widespread musculoskeletal pain, hea-dache and temporomandibular disorder. As a consequence, the potential symptoms are numerous and show a large impact on quality of life. SFN can affect either small sensory fibers, autonomic fibers or both, resulting in sensory changes, autonomic dysfunction or combined symptoms. Incidence and prevalence are estimated to be 12/100.000 and 53/100.000 respectively and are expected to rise with increasing awareness of SFN worldwide. Small fiber neuropathy (SFN) is a disorder of the small myelinated A δ-fibers and unmyelinated C-fibers.
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